The key matchup will be Lille's Jonathan David against Rennes' defensive midfielder Baptiste Santamaria, whose ability to disrupt play will be crucial.
Lille has shown stronger recent form, with four wins in their last five league matches, including a dominant 3-0 victory over Reims. Rennes, despite a decent overall record, has been inconsistent, dropping points in winnable games against lower-table opposition and struggling to maintain defensive solidity.
Lille will secure a narrow 2-1 victory.
Predictions are for entertainment purposes only. Not gambling advice.